Quick Answer
Yes. Urgent care commonly treats acute GI illness with anti-nausea medication (including ondansetron), IV fluids when needed, and a workup to rule out causes that require escalation. Severe abdominal pain, persistent vomiting of blood, or signs of dehydration in a high-risk patient need the ER.
This question comes up frequently for patients researching urgent care at Good Health NC in Knightdale, NC.