Quick Answer
Generally, after two or more well-dosed trials of antidepressants haven't produced adequate response — what's called treatment-resistant depression. TMS is non-invasive, FDA-cleared, and covered by Medicare and most commercial plans after documented medication failures. Ketamine (IV or Spravato nasal spray) is another option for treatment-resistant cases. We help you evaluate which path fits your situation and insurance. See our [TMS therapy](/services/mental-health/tms-therapy) and [ketamine therapy](/services/mental-health/ketamine-therapy) pages for details.
This question comes up frequently for patients researching depression treatment at Good Health NC in Knightdale, NC.