Quick Answer
About one-third of patients don't get adequate relief from the first antidepressant they try, and that's a normal part of finding the right fit — not a sign that treatment won't work. Options include increasing the dose, switching to a different agent, adding a second medication (augmentation), or moving to advanced options like [TMS therapy](/services/mental-health/tms-therapy) or [ketamine therapy](/services/mental-health/ketamine-therapy) for treatment-resistant depression. We work through these steps with you systematically.
This question comes up frequently for patients researching depression treatment at Good Health NC in Knightdale, NC.