Quick Answer
Spravato (esketamine nasal spray) is FDA-approved and covered by Medicare and most major commercial insurance plans after documented antidepressant trials. Prior authorization is required, and we handle that paperwork. IV ketamine is typically used off-label for depression and is usually not covered by insurance — most clinics offering it bill out-of-pocket. We verify your specific coverage and share the cost expectations before you start either path.
This question comes up frequently for patients researching ketamine therapy for depression at Good Health NC in Knightdale, NC.